McKittrick–Wheelock syndrome is a rare but life-threatening condition characterised by severe diarrhoea, electrolyte disturbances, and kidney injury caused by colorectal tumours [1]. The majority of reported cases have been managed by surgical resection [2]. We demonstrate a case of McKittrick–Wheelock syndrome managed endoscopically by speedboat-assisted endoscopic submucosal dissection (S-ESD). S-ESD involves the use of a novel endoscopic electrosurgical device combining advanced bipolar radiofrequency for dissection and microwave energy for coagulation ([Video 1]). This technique was selected to enable en-bloc resection with the potential for organ preservation, while minimising the risks associated with surgery below the peritoneal reflection, particularly in an elderly patient with multiple co-morbidities.

Sourced from: Thieme Endoscopy online, 22 May 2025

Authors:

• Shi Jie Looi  - Gastroenterology Department, University College London Hospitals NHS Foundation Trust, London, United Kingdom (Ringgold ID: RIN8964)
• Omer Ahmad - Gastroenterology Department, University College London Hospitals NHS Foundation Trust, London, United Kingdom (Ringgold ID: RIN8964)
• Edward Seward - Gastroenterology Department, University College London Hospitals NHS Foundation Trust, London, United Kingdom (Ringgold ID: RIN8964)
• Roser Vega - Gastroenterology Department, University College London Hospitals NHS Foundation Trust, London, United Kingdom (Ringgold ID: RIN8964)